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ORIGINAL ARTICLE
Year : 2015  |  Volume : 2  |  Issue : 1  |  Page : 30-36

A prospective trial comparing sequential day 3/day 5 transfer with cleavage stage transfer and blastocyst stage transfer


Department of IVF, Lilavati Hospital and Research Centre, Bandra West, Mumbai, Maharashtra, India

Correspondence Address:
Dr. Rutvij Dalal
20, Shreerang society, Near Old Pilot Dairy, Kankaria, Ahmedabad - 380 022
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2348-2907.151972

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The purpose of this study was to critically evaluate the effect of sequential embryo transfer in randomized patients undergoing assisted in vitro conception. A randomized prospective study was conducted and the outcomes of 505 patients were analyzed, of which 107 women underwent sequential embryo transfer on day 3 and day 5 (D3/D5 group), 283 women underwent day-3 embryo transfer only (D3 control group) and 115 women underwent day-5 embryo transfer only (D5 control group) in the assisted reproduction center of Lilavati Hospital, Mumbai from March 2012 to March 2013. The results showed that the clinical pregnancy rate of the D3/D5 group was significantly higher than that of the D3 group (48.5% versus 29.3%), whereas the clinical pregnancy rates of the D3/D5 and D5 groups were not significantly different (48.5% vs. 53.0%). Day-3/day-5 sequential embryo transfer yields satisfactory clinical pregnancy rates in a subset of patients with repeated implantation failures (35.2%), while avoiding cycle cancellation that happened with about 11% patients that were meant for blastocyst only transfer.


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